Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | MTOR | P42345 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL188523 | 0.88 | MAPK1 (0.66) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL188644 | 0.83 | ALDH1A1 (0.64) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL14301327 | 0.76 | ALDH1A1 (0.56) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL12458504 | 0.75 | RXFP1 (0.54) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL188695 | 0.68 | ALDH1A1 (1.00) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL188921 | 0.67 | MAPK1 (0.58) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL26723719 | 0.67 | KMT2A (0.48) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL1899279 | 0.67 | ALDH1A1 (0.74) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL20614374 | 0.67 | ALDH1A1 (0.55) | MAPK1KDM4EALDH1A1HPGDGAA | |
| SCHEMBL188562 | 0.67 | ALDH1A1 (0.70) | MAPK1KDM4EALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-B9 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2056829-B1 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS INC (US) | 2012-01-04 | — | — | EP | disclosed |