Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.38 |
| ▸ | RAF1 | P04049 | 5/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 5/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
| ▸ | FLT1 | P17948 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26330725 | 0.91 | MAP2K1 (0.39) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL24849671 | 0.91 | MAP2K1 (0.40) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL23694100 | 0.84 | CSF1R (0.40) | MAP2K1MAP2K2CSF1RHDAC3HDAC1 | |
| SCHEMBL26329050 | 0.84 | MAP2K1 (0.39) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL29425298 | 0.82 | MAP2K1 (0.42) | MAP2K1MAP2K2BRAFKDR | |
| SCHEMBL23693880 | 0.82 | MAP2K1 (0.42) | MAP2K1MAP2K2BRAFKDR | |
| SCHEMBL24849393 | 0.79 | MAP2K1 (0.43) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL24927590 | 0.78 | AURKA (0.43) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL24849619 | 0.77 | MAP2K1 (0.42) | MAP2K1RAF1MAP2K2BRAFCYP2C9 | |
| SCHEMBL23693891 | 0.77 | CSF1R (0.42) | MAP2K1MAP2K2CSF1RHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230270730-A1 | COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230270730-A1 | COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE | BRAF, NRAS, KRAS | MAP2K1 17/4885RAF1 4/4885MAP2K2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.