Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.39 |
| ▸ | BRAF | P15056 | 2/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.36 |
| ▸ | RAF1 | P04049 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.34 |
| ▸ | ADCK1 | Q86TW2 | 1/20 | 0.34 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26330721 | 0.91 | MAP2K1 (0.38) | MAP2K1BRAFMAP2K2RAF1CYP2C9 | |
| SCHEMBL23693880 | 0.91 | MAP2K1 (0.42) | MAP2K1BRAFMAP2K2PRKCZIARS2 | |
| SCHEMBL29425298 | 0.91 | MAP2K1 (0.42) | MAP2K1BRAFMAP2K2PRKCZIARS2 | |
| SCHEMBL23694097 | 0.85 | MAP2K1 (0.39) | MAP2K1MAP2K2PRKCZIARS2PIM1 | |
| SCHEMBL23694057 | 0.84 | AURKA (0.46) | MAP2K1BRAFAURKATNFRSF1AKDR | |
| SCHEMBL24849671 | 0.82 | MAP2K1 (0.40) | MAP2K1BRAFMAP2K2RAF1CYP2C9 | |
| SCHEMBL29425299 | 0.79 | MAP2K1 (0.45) | MAP2K1BRAFMAP2K2AURKATNFRSF1A | |
| SCHEMBL23693713 | 0.79 | MAP2K1 (0.45) | MAP2K1BRAFMAP2K2AURKATNFRSF1A | |
| SCHEMBL29425459 | 0.78 | AURKA (0.54) | MAP2K1BRAFMAP2K2AURKATNFRSF1A | |
| SCHEMBL23694068 | 0.78 | AURKA (0.54) | MAP2K1BRAFMAP2K2AURKATNFRSF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230270730-A1 | COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230270730-A1 | COMPOSITION CONTAINING ARYLAMIDE DERIVATIVE | BRAF, NRAS, KRAS | MAP2K1 17/4885BRAF 1/4885MAP2K2 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.