SCHEMBL26331783

SCHEMBL26331783

CO[C@@H]1[C@H](OP(=O)(O)OCC2O[C@@H](n3cnc4c(=O)[nH]c(N)nc43)[C@H](O)[C@@H]2O)C(COP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]2O[C@@H](n3c[n+](C)c4c(=O)[nH]c(N)nc43)[C@H](O)[C@@H]2O)O[C@H]1n1cnc2c(N)ncnc21

nearest known ligand 0.62

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
RNASEL Q05823 8/20 0.61
P2RY1 P47900 4/20 0.59
P2RY2 P41231 2/20 0.59
SRC P12931 1/20 0.59
P2RX1 P51575 1/20 0.59
P2RX3 P56373 1/20 0.59
P2RX4 Q99571 1/20 0.59
P2RX2 Q9UBL9 1/20 0.59
ALDH1A1 P00352 1/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
FUT5 Q11128 1/20 0.57
TGM2 P21980 1/20 0.57
MACROD2 A1Z1Q3 1/20 0.56
SIRT6 Q8N6T7 1/20 0.56
MACROD1 Q9BQ69 1/20 0.56
TRPM2 O94759 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25583996 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25896437 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25895037 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25912796 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL27410758 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25912933 1.00 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25584016 0.99 RNASEL (0.62) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL25584009 0.99 RNASEL (0.62) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL26622399 0.98 RNASEL (0.59) RNASELP2RY1P2RY2SRCP2RX1
SCHEMBL30689463 0.98 RNASEL (0.61) RNASELP2RY1P2RY2SRCP2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767548-B2 RNA polymerase variants MODERNATX, INC. (US) 2023-09-26 US disclosed