Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 8/20 | 0.52 |
| ▸ | ACE | P12821 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.51 |
| ▸ | CTRL | P40313 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.50 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.50 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.50 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.50 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.50 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.50 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.50 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.50 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.50 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080727 | 0.90 | PSMB5 (0.52) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL85179 | 0.89 | CAPN1 (0.50) | PSMB5ACETMPRSS11DCTRLCYP3A4 | |
| SCHEMBL12957256 | 0.89 | PSMB5 (0.62) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL84544 | 0.88 | TMPRSS11D (0.51) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL92790 | 0.87 | PSMB5 (0.52) | PSMB5TMPRSS11DCTRLCYP3A4CYP3A5 | |
| SCHEMBL85534 | 0.86 | ACE (0.56) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL13019967 | 0.86 | PSMB5 (0.60) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL17629489 | 0.85 | ACE (0.55) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL17629488 | 0.85 | ACE (0.55) | PSMB5ACEMMP2MMP7MMP9 | |
| SCHEMBL2633256 | 0.85 | ACE (0.55) | PSMB5ACEMMP2MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094928-A1 | COMPOUNDS FOR ENZYME INHIBITION | ONYX THERAPEUTICS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094928-A1 | COMPOUNDS FOR ENZYME INHIBITION | ANPEP, DNPEP, CPN1 | PSMB5 24/4885ACE 305/4885MMP2 214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.