Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CTSE | P14091 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633858 | 1.00 | HRH3 (0.43) | HRH3USP30BACE1CTSDCTSE | |
| SCHEMBL2633791 | 0.97 | HRH3 (0.41) | HRH3USP30BACE1CTSDCTSE | |
| SCHEMBL2633886 | 0.87 | HRH3 (0.33) | HRH3 | |
| SCHEMBL2633837 | 0.87 | HRH3 (0.39) | HRH3 | |
| SCHEMBL2633804 | 0.87 | HRH3 (0.34) | HRH3 | |
| Hydrochloric Acid SCHEMBL2637048 | 0.86 | HRH3 (0.38) | HRH3 | |
| SCHEMBL2470234 | 0.86 | HRH3 (0.45) | HRH3USP30BACE1CTSDCTSE | |
| SCHEMBL2470175 | 0.86 | HRH3 (0.45) | HRH3USP30BACE1CTSDCTSE | |
| SCHEMBL2473225 | 0.86 | HRH3 (0.45) | HRH3USP30BACE1CTSDCTSE | |
| SCHEMBL2477096 | 0.86 | HRH3 (0.45) | HRH3USP30BACE1CTSDCTSE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569304-A1 | SUBSTITUTED N-HETEROARYL SPIROLACTAM BIPYRROLIDINES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143148-A1 | SUBSTITUTED N-HETEROARYL SPIROLACTAM BIPYRROLIDINES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | disclosed |