Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7878513 | 0.89 | MAPT (0.53) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL12288367 | 0.80 | MAPT (0.50) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL6073396 | 0.78 | MAPT (0.61) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL11820448 | 0.78 | RECQL (0.48) | ALDH1A1MAPTGAAGSK3AGSK3B | |
| SCHEMBL11820453 | 0.78 | RECQL (0.48) | ALDH1A1MAPTGAAGSK3AGSK3B | |
| SCHEMBL24796120 | 0.75 | MAPT (0.54) | ALDH1A1MAPTGAASMN1; SMN2POLB | |
| SCHEMBL9068830 | 0.74 | MAPT (0.58) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL11173506 | 0.74 | MAPT (0.56) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL2360918 | 0.74 | MAPT (0.56) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 | |
| SCHEMBL1693423 | 0.74 | MAPT (0.56) | ALDH1A1MAPTGAASMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011149841-A1 | SUBSTITUTED THIAZOLIDINEDIONE INDAZOLES, INDOLES AND BENZOTRIAZOLES AS ESTROGEN-RELATED RECEPTOR-α MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-12-01 | — | — | WO | disclosed |