Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.68 |
| ▸ | HRH1 | P35367 | 3/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.68 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.68 |
| ▸ | HTR2A | P28223 | 2/20 | 0.68 |
| ▸ | HTR2C | P28335 | 2/20 | 0.68 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.68 |
| ▸ | DRD3 | P35462 | 2/20 | 0.68 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.68 |
| ▸ | HTR2B | P41595 | 2/20 | 0.68 |
| ▸ | KLF10 | Q13118 | 2/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212613 | 1.00 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL4624371 | 1.00 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| Hydrochloric Acid SCHEMBL3269598 | 0.98 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| Oxalic Acid SCHEMBL4936002 | 0.93 | SLC6A2 (0.59) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL21800806 | 0.86 | SLC6A2 (0.53) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL14188841 | 0.85 | SLC6A2 (0.69) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL8079421 | 0.85 | SLC6A2 (0.69) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL14415667 | 0.84 | SLC6A2 (0.50) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL5306302 | 0.83 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 | |
| SCHEMBL2208714 | 0.83 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6SLC6A3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009141833-A2 | AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE | IND-SWIFT LABORATORIES LIMITED (IN) | 2009-11-26 | — | — | WO | claimed |
| WO-2008026227-A2 | A PROCESS FOR THE PREPARATION OF ATOMOXETINE HYDROCHLORIDE | MATRIX LABORATORIES LTD (IN) | 2008-03-06 | — | — | WO | claimed |
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | claimed |
| US-4314081-A | ANTIDEPRESSANTS | ELI LILLY AND COMPANY (US) | 1982-02-02 | — | — | US | claimed |
| US-9604906-B2 | Process for the preparation of 3-aryloxy-3-phenylpropylamine and salt thereof | ZCL CHEMICALS LIMITED (IN) | 2017-03-28 | — | — | US | disclosed |
| US-20160107983-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE AND SALT THEREOF | COHANCE LIFESCIENCES LIMITED (IN) | 2016-04-21 | — | — | US | disclosed |
| WO-2015001565-A2 | \"AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3- PHENYLPROPYLAMINE AND SALT THEREOF\ | ZCL CHEMICALS LIMITED (IN) | 2015-01-08 | — | — | WO | disclosed |
| EP-2536717-B1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-06-04 | — | — | EP | disclosed |
| EP-2536716-B1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-05-21 | — | — | EP | disclosed |
| EP-2536717-A1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-12-26 | — | — | EP | disclosed |
| EP-2536716-A1 | AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-12-26 | — | — | EP | disclosed |
| EP-2513096-A1 | SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-A MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2012-10-24 | — | — | EP | disclosed |
| US-20050209341-A1 | Inhibitor of monoamine uptake | MATTIUZ EDWARD L | 2005-09-22 | — | — | US | disclosed |
| EP-1569905-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004052858-A2 | INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-06-24 | — | — | WO | disclosed |
| US-20040082666-A1 | Inhibitor of monoamine uptake | MATTIUZ EDWARD LOUIS (US) | 2004-04-29 | — | — | US | disclosed |
| EP-1379492-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | disclosed |
| WO-2002070457-A1 | INHIBITOR OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2002-09-12 | — | — | WO | disclosed |
| WO-1999018947-A1 | PROCESS TO MAKE CHIRAL COMPOUNDS | ELI LILLY AND COMPANY (US) | 1999-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160107983-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF 3-ARYLOXY-3-PHENYLPROPYLAMINE AND SALT THEREOF | PAH, TYR, NAT1 | SLC6A2 76/4885SLC6A4 162/4885CYP2D6 336/4885 |
| US-20040082666-A1 | Inhibitor of monoamine uptake | SLC18A2, SLC6A2, SLC18A3 | SLC6A2 2/4885SLC6A4 4/4885CYP2D6 307/4885 |
| US-20050209341-A1 | Inhibitor of monoamine uptake | SLC18A2, SLC6A2, SLC18A3 | SLC6A2 2/4885SLC6A4 4/4885CYP2D6 307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.