Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.57 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | HRH1 | P35367 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786903 | 1.00 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL27624612 | 0.82 | CYP3A4 (0.39) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL27351179 | 0.81 | HTT (0.41) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL27765306 | 0.81 | HTT (0.41) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL27275148 | 0.80 | ALDH1A1 (0.41) | HIF1ATDP1KDM4E | |
| SCHEMBL28198796 | 0.80 | ALDH1A1 (0.41) | HIF1ATDP1KDM4E | |
| SCHEMBL27624613 | 0.80 | HCAR2 (0.41) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL11126553 | 0.80 | POLB (0.54) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7272693 | 0.80 | POLB (0.54) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 | |
| SCHEMBL7272691 | 0.80 | POLB (0.54) | CYP3A4CYP2D6CYP1A2CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115594667-B | Benzimidazole compound, and preparation method and application thereof | 北京京佑奇康科技有限公司 | 2024-05-10 | — | — | CN | claimed |
| CN-110872279-B | High-yield synthesis method of nilotinib | 安徽峆一药业股份有限公司 | 2023-09-08 | — | — | CN | claimed |
| CN-113406236-B | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2023-04-18 | — | — | CN | claimed |
| CN-113354573-B | Method for large-scale production of alpha, alpha-terpyridine | 河南阿尔法医药科技有限公司 | 2023-03-17 | — | — | CN | claimed |
| CN-110078706-B | Imatinib derivative and preparation method and application thereof | 浙江师范大学 | 2022-02-01 | — | — | CN | claimed |
| CN-113406236-A | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2021-09-17 | — | — | CN | claimed |
| CN-113354573-A | Method for large-scale production of alpha, alpha-terpyridine | 河南阿尔法医药科技有限公司 | 2021-09-07 | — | — | CN | claimed |
| CN-109289091-B | Composite scaffold for loading mesenchymal stem cells and preparation method thereof | 温州医科大学附属第一医院 | 2021-04-13 | — | — | CN | claimed |
| CN-110872279-A | High-yield synthesis method of nilotinib | 安徽峆一药业股份有限公司 | 2020-03-10 | — | — | CN | claimed |
| CN-103641775-B | The preparation method of 3-dimethylamino-1-(3-pyridyl)-2-propylene-1-ketone | SHANDONG XINQUAN PHARMACEUTICAL CO., LTD. (CN) | 2016-01-20 | — | — | CN | claimed |
| CN-104829597-A | 1H-indol-2-carbohydrazide derivative as well as preparation method and use of derivative | UNIV XIAMEN | 2015-08-12 | — | — | CN | claimed |
| CN-104774192-A | Preparation method for high-purity imatinib | CHANGZHOU KONY PHARMACEUTICAL CO LTD | 2015-07-15 | — | — | CN | claimed |
| CN-102276518-B | Method for preparing 1-(3-pyridyl)-3-dimethylamino-2-propen-1-one | SHANGHAI SINE YELLOW RIVER PHARMACEUTICAL CO LTD | 2015-03-04 | — | — | CN | claimed |
| CN-102382100-B | Preparation method of imatinib | SHANGHAI SUNRISE PHARMACEUTICAL CO LTD | 2014-04-16 | — | — | CN | claimed |
| CN-103641775-A | Preparation method of 3-dimethylamino-1-(3-pyridyl)-2-propylene-1-one | SHANDONG XINQUAN PHARMACEUTICAL CO LTD | 2014-03-19 | — | — | CN | claimed |
| CN-101928277-B | Preparation method of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidyl]amino]benzoic acid, related intermediate and application thereof | ZHEJIANG JIUZHOU PHARM CO LTD | 2012-09-19 | — | — | CN | claimed |
| CN-102382100-A | Preparation method of imatinib | SHANGHAI SUNRISE PHARMACEUTICAL CO LTD | 2012-03-21 | — | — | CN | claimed |
| CN-102276518-A | Novel method for preparing 1-(3-pyridyl)-3-dimethylamino-2propen-1-one | — | 2011-12-14 | — | — | CN | claimed |
| CN-101928277-A | Preparation method of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidyl]amino]benzoic acid, related intermediate and application thereof | ZHEJIANG JIUZHOU PHARM CO LTD | 2010-12-29 | — | — | CN | claimed |
| CN-115594667-B | Benzimidazole compound, and preparation method and application thereof | 北京京佑奇康科技有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-110872279-B | High-yield synthesis method of nilotinib | 安徽峆一药业股份有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-110872279-B | High-yield synthesis method of nilotinib | 安徽峆一药业股份有限公司 | 2023-09-08 | — | — | CN | disclosed |
| CN-113406236-B | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-113406236-B | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-113354573-B | Method for large-scale production of alpha, alpha-terpyridine | 河南阿尔法医药科技有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-110078706-B | Imatinib derivative and preparation method and application thereof | 浙江师范大学 | 2022-02-01 | — | — | CN | disclosed |
| CN-113406236-A | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2021-09-17 | — | — | CN | disclosed |
| CN-113406236-A | Method for detecting impurities in 1- (3-pyridyl) -3- (dimethylamino) -2-propylene-1-ketone | 海南鑫开源医药科技有限公司 | 2021-09-17 | — | — | CN | disclosed |
| CN-113354573-A | Method for large-scale production of alpha, alpha-terpyridine | 河南阿尔法医药科技有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-109289091-B | Composite scaffold for loading mesenchymal stem cells and preparation method thereof | 温州医科大学附属第一医院 | 2021-04-13 | — | — | CN | disclosed |
| CN-109734708-B | Pyrimidine indole Nur77 receptor regulator and preparation method and application thereof | 厦门大学 | 2021-04-09 | — | — | CN | disclosed |
| CN-111039921-A | Synthesis process of imatinib and imatinib mesylate | 杭州沧海帆医药科技有限公司 | 2020-04-21 | — | — | CN | disclosed |
| CN-110872279-A | High-yield synthesis method of nilotinib | 安徽峆一药业股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| CN-106390950-A | Granulated absorbent for adsorbing acrylonitrile and preparation method thereof | 北京益净环保设备科技有限公司 | 2017-02-15 | — | — | CN | disclosed |
| CN-106334528-A | Function board for adsorbing parathion-methyl, and preparation method of function board | 北京益净环保设备科技有限公司 | 2017-01-18 | — | — | CN | disclosed |
| CN-103641775-B | The preparation method of 3-dimethylamino-1-(3-pyridyl)-2-propylene-1-ketone | SHANDONG XINQUAN PHARMACEUTICAL CO., LTD. (CN) | 2016-01-20 | — | — | CN | disclosed |
| CN-103641775-B | The preparation method of 3-dimethylamino-1-(3-pyridyl)-2-propylene-1-ketone | SHANDONG XINQUAN PHARMACEUTICAL CO., LTD. (CN) | 2016-01-20 | — | — | CN | disclosed |
| CN-104829597-A | 1H-indol-2-carbohydrazide derivative as well as preparation method and use of derivative | UNIV XIAMEN | 2015-08-12 | — | — | CN | disclosed |
| CN-104774192-A | Preparation method for high-purity imatinib | CHANGZHOU KONY PHARMACEUTICAL CO LTD | 2015-07-15 | — | — | CN | disclosed |
| CN-102276518-B | Method for preparing 1-(3-pyridyl)-3-dimethylamino-2-propen-1-one | SHANGHAI SINE YELLOW RIVER PHARMACEUTICAL CO LTD | 2015-03-04 | — | — | CN | disclosed |
| CN-104341387-A | Method for preparing N-(2-methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidinamine | SHANGHAI ACEBRIGHT PHARMACEUTICAL CO LTD | 2015-02-11 | — | — | CN | disclosed |
| CN-102382100-B | Preparation method of imatinib | SHANGHAI SUNRISE PHARMACEUTICAL CO LTD | 2014-04-16 | — | — | CN | disclosed |
| CN-103664874-A | Preparation method of antineoplastic drug imatinib | SHENYANG J & HEALTH PHARAMACEUTICAL CO LTD | 2014-03-26 | — | — | CN | disclosed |
| CN-103641775-A | Preparation method of 3-dimethylamino-1-(3-pyridyl)-2-propylene-1-one | SHANDONG XINQUAN PHARMACEUTICAL CO LTD | 2014-03-19 | — | — | CN | disclosed |
| US-8609842-B2 | Method for synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO., LTD. (CN) | 2013-12-17 | — | — | US | disclosed |
| CN-102234263-B | Method for preparing anti-tumor medicine imatinib | UNIV EAST CHINA SCIENCE & TECH | 2013-08-28 | — | — | CN | disclosed |
| CN-101654416-B | N-[3-nitro-4-methyl-phenyl]-4-aldehyde group-benzamide and preparation method thereof as well as preparation method of derivatives thereof | CHENGDU SHENHUANG MEDICINE TECHNOLOGY CO LTD | 2013-06-05 | — | — | CN | disclosed |
| CN-101735196-B | Method for synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO LTD | 2013-03-20 | — | — | CN | disclosed |
| US-20130041149-A1 | New Method for Synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO., LTD. (CN) | 2013-02-14 | — | — | US | disclosed |
| CN-101497601-B | Process for synthesizing imatinib | FUJIAN SOUTH PHARMACEUTICAL CO LTD | 2012-11-07 | — | — | CN | disclosed |
| CN-101928277-B | Preparation method of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidyl]amino]benzoic acid, related intermediate and application thereof | ZHEJIANG JIUZHOU PHARM CO LTD | 2012-09-19 | — | — | CN | disclosed |
| CN-101417995-B | Phenoxy pyrimidine derivates and preparation method and use thereof | YIJUN CHEN | 2012-06-06 | — | — | CN | disclosed |
| CN-102382100-A | Preparation method of imatinib | SHANGHAI SUNRISE PHARMACEUTICAL CO LTD | 2012-03-21 | — | — | CN | disclosed |
| CN-102372690-A | Intermediate for synthesizing imatinib and application of intermediate in imatinib synthesis | CHENGDU DIAO PHARMACEUTICAL GROUP CO LTD | 2012-03-14 | — | — | CN | disclosed |
| US-20110306763-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | SHANGHAI PARLING PHARMATECH CO., LTD. (CN) | 2011-12-15 | — | — | US | disclosed |
| CN-102276518-A | Novel method for preparing 1-(3-pyridyl)-3-dimethylamino-2propen-1-one | — | 2011-12-14 | — | — | CN | disclosed |
| CN-102234263-A | Method for preparing anti-tumor medicine imatinib | UNIV EAST CHINA SCIENCE & TECH | 2011-11-09 | — | — | CN | disclosed |
| CN-101225085-B | Phenyl urazan nitrogen nitric oxide donor 2-aniline pyrimidine derivatives, preparation method, compound containing the same and use thereof | TIANJIN TASLY GROUP CO LTD | 2011-09-21 | — | — | CN | disclosed |
| CN-101928277-A | Preparation method of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidyl]amino]benzoic acid, related intermediate and application thereof | ZHEJIANG JIUZHOU PHARM CO LTD | 2010-12-29 | — | — | CN | disclosed |
| CN-101735196-A | Method for synthesizing Imatinib | FUJIAN SOUTH PHARMACEUTICAL CO | 2010-06-16 | — | — | CN | disclosed |
| CN-101720322-A | Compounds and compositions as c-kit and pdgfr kinase inhibitors | IRM LLC | 2010-06-02 | — | — | CN | disclosed |
| CN-101687853-A | Pyrimidine derivatives and compositions as C-KIT and PDGFR kinase inhibitors | IRM LLC | 2010-03-31 | — | — | CN | disclosed |
| CN-101687854-A | Compounds and compositions as C-KIT and PDGFR kinase inhibitors | IRM LLC | 2010-03-31 | — | — | CN | disclosed |
| CN-101654416-A | N-[3-nitro-4-methyl-phenyl]-4-aldehyde group-benzamide and preparation method thereof as well as preparation method of derivatives thereof | CHENGDU HUTCHISON CHINA MEDICI | 2010-02-24 | — | — | CN | disclosed |
| CN-101622244-A | Compounds and compositions as protein kinase inhibitors | IRM LLC | 2010-01-06 | — | — | CN | disclosed |
| CN-101497601-A | Process for synthesizing imatinib | SHANGHAI BAILING MEDICINE SCIE (CN) | 2009-08-05 | — | — | CN | disclosed |
| CN-101468984-A | N-oxyde of n-phenyl-2-pyrimidine-amine derivatives | NOVARTIS PHARMA GMBH (CH) | 2009-07-01 | — | — | CN | disclosed |
| CN-101417995-A | Phenoxy pyrimidine derivates and its production and use | YIJUN CHEN (CN) | 2009-04-29 | — | — | CN | disclosed |
| CN-100467461-C | N-oxides of N-phenyl-2-pyrimidine-amine derivatives | NOVARTIS AG (CH) | 2009-03-11 | — | — | CN | disclosed |
| CN-100451015-C | Preparing method of imatinib | HANGZHOU SHENGMEI MEDICINE TEC (CN) | 2009-01-14 | — | — | CN | disclosed |
| CN-101225085-A | Phenyl urazan nitrogen nitric oxide donor 2-aniline pyrimidine derivatives, preparation method, compound containing the same and use thereof | TIANJIN TASLY GROUP CO LTD (CN) | 2008-07-23 | — | — | CN | disclosed |
| CN-100347162-C | N-phenyl-2-pyrimidinamine derivatives | NOVARTIS AG (CH) | 2007-11-07 | — | — | CN | disclosed |
| CN-101045727-A | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2007-10-03 | — | — | CN | disclosed |
| CN-101016262-A | N-phenyl-2-pyrimidine-amine derivatives | NOVARTIS AG (CH) | 2007-08-15 | — | — | CN | disclosed |
| CN-101016293-A | Preparing method of imatinib | HANGZHOU SHENGMEI MEDICINE TEC (CN) | 2007-08-15 | — | — | CN | disclosed |
| CN-1324022-C | Tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2007-07-04 | — | — | CN | disclosed |
| CN-1675195-A | Tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2005-09-28 | — | — | CN | disclosed |
| CN-1646519-A | N-oxides of N-phenyl-2-pyrimidine-amine derivatives | NOVARTIS AG (CH) | 2005-07-27 | — | — | CN | disclosed |
| CN-1630648-A | N-phenyl-2-pyrimidinamine derivatives | NOVARTIS AG (CH) | 2005-06-22 | — | — | CN | disclosed |
| CN-1043531-C | Pyrimidine derivatives and a process for production thereof | NOVATIS AG (CH) | 1999-06-02 | — | — | CN | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |
| CN-1077713-A | Pyrimidine derivatives and preparation method thereof | CIBA GEIGY AG (CH) | 1993-10-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306763-A1 | PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF | ABL1, JAK2, ABL2 | CYP3A4 889/4885CYP2D6 594/4885CYP1A2 2458/4885 |
| US-20130041149-A1 | New Method for Synthesizing Imatinib | ABL1, ALK, PDGFRA | CYP3A4 100/4885CYP2D6 136/4885CYP1A2 166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.