Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12733389 | 1.00 | NPSR1 (0.48) | NPSR1CYP3A4CYP2D6LMNAKDM4E | |
| SCHEMBL12733433 | 0.95 | NPSR1 (0.47) | NPSR1CYP3A4CYP2D6LMNAKDM4E | |
| SCHEMBL12733387 | 0.90 | NPSR1 (0.59) | NPSR1CYP3A4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL21696640 | 0.90 | NPSR1 (0.59) | NPSR1CYP3A4CYP2D6KDM4EALDH1A1 | |
| SCHEMBL12733388 | 0.89 | NPSR1 (0.54) | NPSR1FKBP1AEPHX1L3MBTL1NAAA | |
| SCHEMBL12733395 | 0.87 | NAAA (0.56) | NPSR1KDM4EFKBP1AEPHX1NAAA | |
| SCHEMBL17817483 | 0.87 | NAAA (0.56) | NPSR1KDM4EFKBP1AEPHX1NAAA | |
| SCHEMBL12733386 | 0.87 | NAAA (0.56) | NPSR1KDM4EFKBP1AEPHX1NAAA | |
| SCHEMBL12733385 | 0.87 | NAAA (0.56) | NPSR1KDM4EFKBP1AEPHX1NAAA | |
| SCHEMBL5737180 | 0.86 | CYP3A4 (0.47) | NPSR1CYP3A4CYP2D6LMNAFKBP1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230303514-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2023-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230303514-A1 | TLR7/8 ANTAGONISTS AND USES THEREOF | TLR7, TLR8, TLR9 | NPSR1 1200/4885CYP3A4 3093/4885CYP2D6 2791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.