SCHEMBL26351069

SCHEMBL26351069

CCCCc1nc2c(N)nc3ccccc3c2n1CCCCNC(=O)c1ccc(CCN)cc1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.79
TLR8 Q9NR97 7/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26346805 0.96 TLR7 (0.80) TLR7TLR8
SCHEMBL29475735 0.93 TLR7 (0.78) TLR7TLR8
SCHEMBL22359220 0.93 TLR7 (0.78) TLR7TLR8
SCHEMBL3867030 0.92 TLR7 (0.79) TLR7TLR8
SCHEMBL3869663 0.91 TLR7 (0.81) TLR7TLR8
SCHEMBL3864075 0.90 TLR7 (0.80) TLR7TLR8
SCHEMBL20487533 0.90 TLR7 (0.75) TLR7TLR8
Hydrochloric Acid SCHEMBL21800937 0.89 TLR7 (0.74) TLR7TLR8
SCHEMBL26351131 0.89 TLR7 (0.62) TLR7TLR8
SCHEMBL26351203 0.88 TLR7 (0.73) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF AMBRX, INC. (US) 2023-09-28 US disclosed
CN-113660957-A Compositions, methods, and uses comprising antibody-TLR agonist conjugates AMBRX公司 2021-11-16 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230302150-A1 ANTIBODY-TLR AGONIST CONJUGATES, METHODS AND USES THEREOF TLR3, TLR1, TLR9 TLR7 4/4885TLR8 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.