Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 7/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 5/20 | 0.44 |
| ▸ | CTSL | P07711 | 4/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25401074 | 0.90 | ATM (0.47) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL25401078 | 0.90 | ATM (0.47) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL5826373 | 0.88 | CTSS (0.48) | ATMSYKCTSKCTSSCTSL | |
| SCHEMBL5724014 | 0.86 | ATM (0.50) | ATMSYKCTSKCTSSCTSL | |
| SCHEMBL23455702 | 0.86 | PPARA (0.51) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL10045788 | 0.86 | PPARA (0.51) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL13727930 | 0.86 | CTSS (0.43) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL13727926 | 0.86 | CTSS (0.43) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL5724195 | 0.85 | SYK (0.52) | ATMSYKCTSKITGB3ITGA2B | |
| SCHEMBL10045790 | 0.83 | CTSS (0.49) | ATMSYKCTSKITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133908-B2 | Heteroaryl derivatives of N-{[(1S,4S,6S)-3-(2-pyridinylcarbonyl)-3-azabicyclo[4.1.0]hept-4-yl]methyl}-2-amine | GLAXO GROUP LIMITED (GB) | 2012-03-13 | — | — | US | disclosed |