Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.41 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.41 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.41 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2636805 | 0.97 | SLCO1B1 (0.38) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2635538 | 0.95 | SLC6A9 (0.40) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2635693 | 0.93 | LPAR1 (0.48) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2635736 | 0.90 | LPAR1 (0.45) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2761762 | 0.89 | SLCO1B1 (0.34) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2636376 | 0.89 | LPAR1 (0.44) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2761409 | 0.87 | SLCO1B1 (0.33) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2761822 | 0.85 | SLCO1B1 (0.36) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL6894 | 0.82 | SLC6A9 (0.41) | ABCC3ABCC4ABCB11CYP2C8CYP2C9 | |
| SCHEMBL2761346 | 0.82 | CA12 (0.40) | LPAR1SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438048-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010141768-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |
| WO-2010141761-A2 | POLYCYCLIC ANTAGONISTS OF LYSOPHOSPHATIDIC ACID RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2010-12-09 | — | — | WO | disclosed |