Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13754028 | 0.89 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL1311332 | 0.88 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL8312142 | 0.85 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4DCSF1R | |
| SCHEMBL4948607 | 0.85 | PDE4B (0.68) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4948999 | 0.85 | PDE4B (0.65) | PDE4BPDE4APDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL2479683 | 0.85 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4948631 | 0.84 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4951341 | 0.84 | PDE4B (0.66) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL4627512 | 0.83 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4DTP53 | |
| SCHEMBL28298884 | 0.83 | TSHR (0.53) | PDE4BTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569285-A1 | BIFUNCTIONAL QUINOLINE DERIVATIVES | Gilead Sciences, Inc. (US) | 2013-03-20 | — | — | EP | claimed |
| WO-2011143105-A1 | BIFUNCTIONAL QUINOLINE DERIVATIVES | GILEAD SCIENCES, INC. (US) | 2011-11-17 | — | — | WO | claimed |