Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | NUDT1 | P36639 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26360411 | 0.85 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2ALOX5APNUDT1 | |
| SCHEMBL26360426 | 0.83 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2ALOX5APNUDT1 | |
| SCHEMBL26360415 | 0.79 | POLB (0.49) | NPC1RAB9ASMN1; SMN2ALOX5APNUDT1 | |
| SCHEMBL23998057 | 0.78 | KDM4E (0.45) | ALOX5APPOLBLMNACYP1A2CYP2C19 | |
| SCHEMBL30322679 | 0.78 | KDM4E (0.45) | ALOX5APPOLBLMNACYP1A2CYP2C19 | |
| SCHEMBL4528068 | 0.75 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2NUDT1POLB | |
| SCHEMBL4537266 | 0.72 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2NUDT1POLB | |
| SCHEMBL3946470 | 0.71 | HSP90AA1 (0.56) | CYP1A2HSP90AA1HSP90AB1CYP2C9CYP2D6 | |
| SCHEMBL26360421 | 0.71 | GRM4 (0.36) | NUDT1CYP1A2HSP90AA1GRM4MAPT | |
| SCHEMBL4535234 | 0.71 | CYP1A2 (0.57) | NPC1RAB9ASMN1; SMN2NUDT1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | ELI LILLY AND COMPANY (US) | 2023-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | P2RX1, P2RX2, P2RY1 | NPC1 2417/4885RAB9A 1346/4885SMN1; SMN2 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.