Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26360411 | 0.83 | SMN1; SMN2 (0.48) | POLBSMN1; SMN2NPC1RAB9ANUDT1 | |
| SCHEMBL26360426 | 0.81 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2NPC1RAB9ANUDT1 | |
| SCHEMBL23998093 | 0.81 | KDM4E (0.41) | POLBALOX5APCYP1A2CYP2C19LMNA | |
| SCHEMBL30322714 | 0.81 | KDM4E (0.41) | POLBALOX5APCYP1A2CYP2C19LMNA | |
| SCHEMBL26360412 | 0.79 | NPC1 (0.50) | POLBSMN1; SMN2NPC1RAB9ANUDT1 | |
| SCHEMBL7363505 | 0.77 | SMN1; SMN2 (0.62) | POLBSMN1; SMN2NPC1RAB9ANUDT1 | |
| SCHEMBL26360419 | 0.76 | CYP1A2 (0.36) | POLBCYP1A2CYP2C19CYP2C9CYP3A4 | |
| SCHEMBL26360438 | 0.74 | CYP1A2 (0.34) | CYP1A2CYP2C19CYP2C9CYP3A4ABCC3 | |
| SCHEMBL30322701 | 0.72 | HTT (0.33) | POLBSMN1; SMN2CYP1A2CYP2C19LMNA | |
| SCHEMBL23998071 | 0.72 | HTT (0.33) | POLBSMN1; SMN2CYP1A2CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | ELI LILLY AND COMPANY (US) | 2023-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773067-B2 | (Trifluoromethyl)pyrimidine-2-amine compounds | P2RX1, P2RX2, P2RY1 | POLB 1109/4885SMN1; SMN2 53/4885NPC1 2417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.