Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495327 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL29436163 | 0.88 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL29436224 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1MAPTTP53NPC1 | |
| SCHEMBL23495418 | 0.81 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1MAPTTP53NPC1 | |
| SCHEMBL29436225 | 0.79 | TP53 (0.60) | SMN1; SMN2ALDH1A1MAPTTP53 | |
| SCHEMBL23495355 | 0.79 | TP53 (0.60) | SMN1; SMN2ALDH1A1MAPTTP53 | |
| SCHEMBL23297214 | 0.77 | PDE4B (0.60) | SMN1; SMN2PTGDR2PDE5APDE4BPDE3A | |
| SCHEMBL29776795 | 0.77 | PDE4B (0.60) | SMN1; SMN2PTGDR2PDE5APDE4BPDE3A | |
| SCHEMBL23495178 | 0.76 | MAPT (0.49) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL29436219 | 0.76 | MAPT (0.49) | MEN1KMT2AALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248972-A2 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-09-27 | — | — | EP | disclosed |