SCHEMBL2636397

SCHEMBL2636397

NC(=NO)c1ccc(C2CCCCC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.60
MAPK1 P28482 1/20 0.60
KMT2A Q03164 1/20 0.60
HDAC8 Q9BY41 2/20 0.47
HDAC6 Q9UBN7 2/20 0.47
HDAC1 Q13547 1/20 0.47
NOS3 P29474 2/20 0.45
NOS1 P29475 2/20 0.45
NOS2 P35228 2/20 0.45
HAO1 Q9UJM8 1/20 0.45
KDM4E B2RXH2 1/20 0.44
HDAC3 O15379 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
DEGS1 O15121 1/20 0.43
KDM1A O60341 1/20 0.41
ESR2 Q92731 1/20 0.40
NOTUM Q6P988 1/20 0.39
RAB9A P51151 1/20 0.39
ATM Q13315 1/20 0.39
NAMPT P43490 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2636394 1.00 MEN1 (0.60) MEN1MAPK1KMT2AHDAC8HDAC6
SCHEMBL2328166 0.82 KMT2A (0.57) MEN1MAPK1KMT2AHDAC8HDAC6
SCHEMBL2328170 0.82 KMT2A (0.57) MEN1MAPK1KMT2AHDAC8HDAC6
SCHEMBL4322424 0.78 HDAC8 (0.47) MEN1MAPK1KMT2AHDAC8HDAC6
SCHEMBL2744667 0.77 HDAC8 (0.59) KMT2AHDAC8HDAC6HDAC1HAO1
SCHEMBL507535 0.77 HDAC8 (0.50) KMT2AHDAC8HDAC6HDAC1NOS3
Hydrochloric Acid SCHEMBL4986176 0.76 HDAC8 (0.58) KMT2AHDAC8HDAC6HDAC1HAO1
SCHEMBL14257520 0.75 KDM4E (0.39) MEN1MAPK1KMT2AHDAC8HDAC6
Hydrogen Peroxide SCHEMBL11391495 0.75 HAO1 (0.55) KMT2AHDAC8HDAC6HDAC1HAO1
SCHEMBL17963141 0.75 HDAC8 (0.61) HDAC8HDAC6HDAC1HAO1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2569309-A1 HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES Bayer Intellectual Property GmbH (DE) 2013-03-20 EP disclosed
WO-2011141325-A1 HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-11-17 WO disclosed