Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23495359 | 0.85 | KDM4E (0.52) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL24029943 | 0.81 | MKNK1 (0.49) | POLBKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL23495245 | 0.72 | MEN1 (0.53) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23495246 | 0.72 | TP53 (0.59) | POLBKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL2969915 | 0.71 | PDE4B (0.67) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23513145 | 0.71 | POLB (0.46) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL26627234 | 0.71 | PDE4A (0.53) | POLBMEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL23297341 | 0.71 | PDE4A (0.53) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23495122 | 0.70 | MEN1 (0.45) | POLBMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL23495121 | 0.70 | MEN1 (0.45) | POLBMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248972-A2 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-09-27 | — | — | EP | disclosed |