Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KLK3 | P07288 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24029946 | 0.84 | KDM4E (0.43) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL24030193 | 0.83 | CYP1A2 (0.53) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL29457946 | 0.83 | LMNA (0.64) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL23495359 | 0.82 | KDM4E (0.52) | KDM4EALDH1A1HSD17B10LMNAPOLB | |
| SCHEMBL26364786 | 0.81 | POLB (0.43) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL30297703 | 0.80 | KDM4E (0.45) | KDM4EALDH1A1HSD17B10SMN1; SMN2LMNA | |
| SCHEMBL25969107 | 0.79 | KDM4E (0.69) | KDM4EALDH1A1HSD17B10SMN1; SMN2TSHR | |
| SCHEMBL2969915 | 0.78 | PDE4B (0.67) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL23297341 | 0.77 | PDE4A (0.53) | KDM4EALDH1A1SMN1; SMN2TSHRPOLB | |
| SCHEMBL26627234 | 0.77 | PDE4A (0.53) | KDM4ESMN1; SMN2POLBMAPTPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021231546-A1 | SUBSTITUTED PYRIDAZINONE FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS, INC. (US) | 2021-11-18 | — | — | WO | disclosed |