Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 11/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2633782 | 0.83 | — | — | |
| SCHEMBL2633879 | 0.83 | — | — | |
| SCHEMBL3654536 | 0.80 | FLT3 (0.34) | PARP1IRAK4MKNK1MKNK2SYK | |
| SCHEMBL3650931 | 0.80 | FLT3 (0.34) | PARP1IRAK4MKNK1MKNK2SYK | |
| SCHEMBL2633810 | 0.79 | SLC6A2 (0.31) | — | |
| SCHEMBL2637634 | 0.77 | CCR8 (0.36) | — | |
| SCHEMBL2637208 | 0.75 | HPGD (0.37) | MAPK1 | |
| SCHEMBL3657524 | 0.75 | PARP10 (0.39) | PARP2 | |
| SCHEMBL3655820 | 0.74 | SLC6A2 (0.35) | IRAK4MKNK1MKNK2KCNH2 | |
| Trifluoroacetic Acid SCHEMBL3654252 | 0.74 | FLT3 (0.33) | MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569294-A1 | SUBSTITUTED N-HETEROARYL BIPYRROLIDINE CARBOXAMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-03-20 | — | — | EP | claimed |
| WO-2011143162-A1 | SUBSTITUTED N-HETEROARYL BIPYRROLIDINE CARBOXAMIDES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-11-17 | — | — | WO | claimed |