Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
| ▸ | NEK2 | P51955 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650931 | 0.93 | FLT3 (0.34) | FLT3MKNK1MKNK2 | |
| SCHEMBL3654536 | 0.93 | FLT3 (0.34) | FLT3MKNK1MKNK2 | |
| Trifluoroacetic Acid SCHEMBL3659583 | 0.87 | PARP10 (0.34) | FLT3 | |
| SCHEMBL3655820 | 0.85 | SLC6A2 (0.35) | FLT3MKNK1MKNK2 | |
| Trifluoroacetic Acid SCHEMBL3650183 | 0.83 | MAPK14 (0.33) | — | |
| Trifluoroacetic Acid SCHEMBL3652805 | 0.82 | KDM4E (0.41) | — | |
| Trifluoroacetic Acid SCHEMBL3655804 | 0.80 | CYP1A2 (0.36) | — | |
| SCHEMBL3657524 | 0.79 | PARP10 (0.39) | FLT3 | |
| Trifluoroacetic Acid SCHEMBL3655792 | 0.79 | MAPT (0.37) | — | |
| Trifluoroacetic Acid SCHEMBL3656579 | 0.78 | BCL9 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212283-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052062-A1 | SUBSTITUTED N-PHENYL-BIPYRROLIDINE CARBOXAMIDES AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-04-23 | — | — | WO | disclosed |