Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cilomilast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 20/20 | 1.00 |
| ▸ | PDE4A known ✓ | P27815 | 19/20 | 1.00 |
| ▸ | PDE4C known ✓ | Q08493 | 19/20 | 1.00 |
| ▸ | PDE4D known ✓ | Q08499 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cilomilast SCHEMBL27516 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL13777301 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL5975855 | 1.00 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL6904030 | 0.99 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL29107422 | 0.99 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL7130621 | 0.99 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL7130626 | 0.99 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL7124080 | 0.97 | PDE4B (0.94) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28381093 | 0.96 | PDE4B (0.92) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 14912 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704983-A2 | TREATMENT OF MEMORY LOSS WITH PHOSPHODIESTERASE INHIBITORS | Cyrano Therapeutics, Inc. (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260041690-A1 | Treatment of Memory Loss with Phosphodiesterase Inhibitors | CYRANO THERAPEUTICS INC (US) | 2026-02-12 | — | — | US | claimed |
| WO-2025227007-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | OHIO STATE INNOVATION FOUNDATION (US) | 2025-10-30 | — | — | WO | claimed |
| US-20250312353-A1 | DRUG REPURPOSING FOR TREATMENT OF CONGENITAL VASCULAR MALFORMATIONS | UNIVERSITY OF SOUTH CAROLINA (US) | 2025-10-09 | — | — | US | claimed |
| EP-4565302-A1 | DRY POWDER INHALER | Chiesi Farmaceutici S.p.A. (IT) | 2025-06-11 | — | — | EP | claimed |
| CN-119925269-A | Sivelesta sodium suspension, freeze-dried powder, atomized inhalant and preparation method thereof | 暨南大学 | 2025-05-06 | — | — | CN | claimed |
| US-12268779-B2 | Ophthalmic emulsion | ALCON INC. (CH) | 2025-04-08 | — | — | US | claimed |
| CN-119454985-A | CXCR1 engineering exosome targeting to heart ischemia reperfusion injury area and construction method and application thereof | 南方医科大学南方医院 | 2025-02-18 | — | — | CN | claimed |
| US-20250049770-A1 | Phosphodiesterase 4 Inhibitor Decreases Thrombosis in Simulated ECMO Model | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2025-02-13 | — | — | US | claimed |
| CN-113563246-B | Substituted aza five-membered ring derivative and application thereof in medicines | 广东东阳光药业股份有限公司 | 2025-01-17 | — | — | CN | claimed |
| WO-1999034798-A1 | METHOD FOR TREATING COPD | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-15 | — | — | WO | claimed |
| EP-0919544-A1 | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1999-06-02 | — | — | EP | claimed |
| EP-0749417-A4 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORP (US) | 1999-04-14 | — | — | EP | claimed |
| JP-2873090-B2 | — | — | 1999-03-24 | — | — | JP | claimed |
| EP-0749417-A1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 1996-12-27 | — | — | EP | claimed |
| US-5552438-A | Compounds useful for treating allergic and inflammatory diseases | SMITHKLINE BEECHAM CORPORATION (US) | 1996-09-03 | — | — | US | claimed |
| WO-1995024381-A1 | CYANO COMPOUNDS AND PREPARATIONS THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 1995-09-14 | — | — | WO | claimed |
| EP-0633776-A4 | — | — | 1995-01-25 | — | — | EP | claimed |
| EP-0633776-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1995-01-18 | — | — | EP | claimed |
| WO-1993019749-A1 | COMPOUNDS USEFUL FOR TREATING ALLERGIC AND INFLAMMATORY DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-10-14 | — | — | WO | claimed |