Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cilomilast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B known ✓ | Q07343 | 20/20 | 0.98 |
| ▸ | PDE4A known ✓ | P27815 | 19/20 | 0.98 |
| ▸ | PDE4C known ✓ | Q08493 | 19/20 | 0.98 |
| ▸ | PDE4D known ✓ | Q08499 | 19/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cilomilast SCHEMBL29107422 | 1.00 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL7130621 | 1.00 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27516 | 0.99 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL27515 | 0.99 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL26372 | 0.99 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL13777301 | 0.99 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL5975855 | 0.99 | PDE4B (1.00) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL6904030 | 0.98 | PDE4B (0.98) | PDE4BPDE4APDE4CPDE4D | |
| Cilomilast SCHEMBL7124080 | 0.96 | PDE4B (0.94) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL28381093 | 0.95 | PDE4B (0.92) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117982414-B | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-07-02 | — | — | CN | claimed |
| CN-118161458-A | Freeze-dried preparation of ciliristat sodium and preparation method thereof | 牡丹江市第二人民医院 | 2024-06-11 | — | — | CN | claimed |
| CN-117982414-A | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-05-07 | — | — | CN | claimed |
| CN-116874396-A | Method for preparing high-purity cilansetron sodium | 南京福美瑞信科技有限公司 | 2023-10-13 | — | — | CN | claimed |
| CN-116635018-A | Pharmaceutical composition for inhalation | 上海汇伦医药股份有限公司 | 2023-08-22 | — | — | CN | claimed |
| CN-116115589-A | Sivelesta sodium pharmaceutical composition for inhalation and preparation method thereof | 江苏百奥信康医药科技有限公司 | 2023-05-16 | — | — | CN | claimed |
| CN-117982414-B | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-07-02 | — | — | CN | disclosed |
| CN-118161458-A | Freeze-dried preparation of ciliristat sodium and preparation method thereof | 牡丹江市第二人民医院 | 2024-06-11 | — | — | CN | disclosed |
| CN-118161458-A | Freeze-dried preparation of ciliristat sodium and preparation method thereof | 牡丹江市第二人民医院 | 2024-06-11 | — | — | CN | disclosed |
| CN-117982414-A | Sivelesta sodium nanocrystalline, dry powder and inhalation powder fog agent thereof and preparation method thereof | 暨南大学 | 2024-05-07 | — | — | CN | disclosed |
| CN-115144513-B | Method for determining concentration of cilveliroxostat in organism | 上海谱锐赛思生物技术有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-116354855-B | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116354855-B | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-117398373-A | New application of sivelestat | 上海汇伦医药股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116635018-A | Pharmaceutical composition for inhalation | 上海汇伦医药股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| CN-116354855-A | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-116354855-A | Preparation method of cilansetrot sodium | 江苏百奥信康医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |
| CN-116115589-A | Sivelesta sodium pharmaceutical composition for inhalation and preparation method thereof | 江苏百奥信康医药科技有限公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-116115589-A | Sivelesta sodium pharmaceutical composition for inhalation and preparation method thereof | 江苏百奥信康医药科技有限公司 | 2023-05-16 | — | — | CN | disclosed |
| US-20030013905-A1 | Salts of cis-4-cyano-4[3(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid | SMITHKLINE BEECHAM CORPORATION | 2003-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030013905-A1 | Salts of cis-4-cyano-4[3(cyclopentyloxy)-4-methoxyphenyl]cyclohexane-1-carboxylic acid | CA4, CLIC4, SLC16A3 | PDE4B 2394/4885PDE4A 1692/4885PDE4C 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.