Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 7/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4166705 | 0.90 | MEN1 (0.47) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL4166712 | 0.90 | MEN1 (0.47) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL263637 | 0.78 | MEN1 (0.48) | KMT2AMEN1GAAFOXO1ALOX15 | |
| SCHEMBL4165331 | 0.78 | MEN1 (0.51) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL263552 | 0.77 | KMT2A (0.45) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL266815 | 0.76 | MEN1 (0.54) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL263408 | 0.76 | MEN1 (0.47) | KMT2AMEN1GAAFOXO1PDE10A | |
| SCHEMBL4164634 | 0.75 | MEN1 (0.50) | KMT2AMEN1GAAFOXO1PDE10A | |
| SCHEMBL265623 | 0.75 | KMT2A (0.53) | KMT2AMEN1GAACNR1CNR2 | |
| SCHEMBL13332570 | 0.75 | MEN1 (0.40) | KMT2AMEN1GAACNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |