Demannose

Demannose

SCHEMBL2637762

O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.40
▸ KMT2A Q03164 2/20 0.40
▸ LGALS8 O00214 1/20 0.40
▸ LGALS3 P17931 1/20 0.40
▸ LGALS4 P56470 1/20 0.40
▸ IGF2R P11717 2/20 0.39
▸ PTPN1 P18031 1/20 0.37
▸ GJA1 P17302 1/20 0.37
▸ GJB2 P29033 1/20 0.37
▸ CYP2C9 P11712 1/20 0.37
▸ TSHR P16473 1/20 0.37
▸ ALDH1A1 P00352 1/20 0.37
▸ MAPT P10636 1/20 0.36
▸ AMY2A P04746 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cellobiose SCHEMBL4302484 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Maltose SCHEMBL9738256 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Maltose SCHEMBL537670 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Demannose SCHEMBL8488325 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Maltose SCHEMBL7601981 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Cellobiose SCHEMBL23699869 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Maltose SCHEMBL9518393 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Cellobiose SCHEMBL17941750 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Cellobiose SCHEMBL16058825 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4
Cellobiose SCHEMBL3878771 0.94 LGALS8 (0.44) MEN1KMT2ALGALS8LGALS3LGALS4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024102556-A1 FILAMENTOUS FUNGAL STRAINS COMPRISING ENHANCED PROTEIN PRODUCTIVITY PHENOTYPES AND METHODS THEREOF DANISCO US INC. (US) 2024-05-16 — — WO disclosed
EP-2438164-B1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND/OR STABILITY, AND USE THEREOF DANISCO US INC (US) 2017-08-02 — — EP disclosed
US-9523087-B2 Cellulase variants with improved expression, activity and stability, and use thereof DANISCO US INC (US) 2016-12-20 — — US disclosed
CN-104862293-A Cellulose variants with improved expression, activity and/or stability, and use thereof DANISCO US INC 2015-08-26 — — CN disclosed
CN-102803482-B Cellulase variants with improved expression, activity and/or stability, and uses thereof DANISCO US INC 2015-04-29 — — CN disclosed
US-20140302585-A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF DANISCO US INC. (US) 2014-10-09 — — US disclosed
US-8679816-B2 Cellulase variants with improved expression, activity and stability, and use thereof DANISCO US INC. (US) 2014-03-25 — — US disclosed
CN-102803482-A Cellulase variants with improved expression, activity and/or stability, and uses thereof DANISCO US INC 2012-11-28 — — CN disclosed
US-20120135500-A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF DANISCO US INC. (US) 2012-05-31 — — US disclosed
EP-2438164-A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND/OR STABILITY, AND USE THEREOF Danisco US Inc. (US) 2012-04-11 — — EP disclosed
WO-2010141779-A1 CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND/OR STABILITY, AND USE THEREOF DANISCO US INC. (US) 2010-12-09 — — WO disclosed
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