Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998053 | 0.96 | ALDH1A1 (0.58) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL23269699 | 0.89 | ALDH1A1 (0.51) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL19275359 | 0.84 | ALDH1A1 (0.54) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL23775508 | 0.82 | ALDH1A1 (0.53) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL18389827 | 0.82 | PAOX (0.48) | ALDH1A1LMNAPAOXTSHRHTR1A | |
| SCHEMBL17286057 | 0.81 | ALDH1A1 (0.45) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL15043685 | 0.81 | ALDH1A1 (0.59) | ALDH1A1NPC1LMNARAB9ADRD2 | |
| SCHEMBL16803394 | 0.80 | ALDH1A1 (0.42) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL12325467 | 0.79 | ALDH1A1 (0.58) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL20457594 | 0.79 | ALDH1A1 (0.58) | ALDH1A1NPC1LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-B1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS INC (US) | 2023-09-27 | — | — | EP | disclosed |