SCHEMBL2638525

SCHEMBL2638525

N#Cc1cc(Cl)cc(Oc2c(Cl)ccc(CC(=O)Nc3ccc(S(=O)(=O)NC(=O)CCC(=O)O)cc3Cl)c2F)c1

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.40
SLC22A12 Q96S37 1/20 0.36
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
CA1 P00915 12/20 0.35
CA2 P00918 12/20 0.35
CA9 Q16790 6/20 0.35
CA12 O43570 4/20 0.35
CA5A P35218 2/20 0.35
CA7 P43166 2/20 0.35
CA5B Q9Y2D0 2/20 0.35
AKR1C3 P42330 1/20 0.34
AKR1C2 P52895 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2638833 0.93 CYP3A4 (0.40) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2639819 0.93 CYP3A4 (0.42) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2639193 0.92 CYP3A4 (0.42) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638965 0.91 CYP3A4 (0.41) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638836 0.91 CYP3A4 (0.41) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638424 0.91 CYP3A4 (0.43) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638373 0.91 CYP3A4 (0.41) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638882 0.90 CYP3A4 (0.42) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL2638552 0.89 CYP3A4 (0.42) CYP3A4SLC22A12CYP2C9CYP2C19CA1
SCHEMBL3833407 0.89 CYP3A4 (0.42) CYP3A4SLC22A12CYP2C9CYP2C19CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4810529-B2 2011-11-09 JP claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP claimed
EP-1742908-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-01-17 EP claimed
WO-2005102989-A1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2005-11-03 WO claimed
EP-1742908-B1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2009-11-11 EP disclosed