Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.33 |
| ▸ | MYLK2 | Q9H1R3 | 2/20 | 0.33 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | ULK3 | Q6PHR2 | 1/20 | 0.32 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | NIM1K | Q8IY84 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26388979 | 0.89 | LRRK2 (0.30) | LRRK2 | |
| SCHEMBL14996621 | 0.82 | PDE10A (0.34) | CSF1RMYLK2MARK4HDAC9LRRK2 | |
| SCHEMBL1358932 | 0.81 | LRRK2 (0.38) | LRRK2PDE10A | |
| SCHEMBL24977209 | 0.78 | HDAC9 (0.31) | HDAC9PDE10A | |
| SCHEMBL5021084 | 0.78 | CSF1R (0.34) | CSF1RMYLK2MARK4LRRK2MKNK2 | |
| SCHEMBL16532100 | 0.78 | MARK4 (0.38) | CSF1RMYLK2MARK4HDAC9LRRK2 | |
| SCHEMBL25679963 | 0.78 | CSF1R (0.32) | CSF1RMYLK2MARK4LRRK2MKNK2 | |
| SCHEMBL12871628 | 0.77 | L3MBTL1 (0.42) | CSF1RMYLK2MARK4HDAC9LRRK2 | |
| SCHEMBL12859176 | 0.77 | LRRK2 (0.33) | CSF1RMYLK2MARK4LRRK2MKNK2 | |
| SCHEMBL24977207 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192901-A9 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023192901-A1 | QUINOLINE DERIVATIVES AS MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |