Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | CDK7 | P50613 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26394074 | 0.90 | HDAC6 (0.43) | MAP2K4HDAC6PAK1GSK3BCYP1A2 | |
| SCHEMBL26393770 | 0.89 | PRKAA1 (0.47) | HDAC6PAK1GSK3BCYP1A2PRKAA1 | |
| SCHEMBL26393893 | 0.87 | PAK1 (0.53) | HDAC6PAK1GSK3BCYP1A2PRKAA1 | |
| SCHEMBL26393881 | 0.85 | GSK3B (0.42) | MAP2K4PAK1GSK3BCYP1A2CDK7 | |
| SCHEMBL26393577 | 0.84 | FADS1 (0.47) | HDAC6PAK1GSK3BCDK7PRKAA1 | |
| SCHEMBL26393862 | 0.82 | GSK3B (0.45) | HDAC6PAK1GSK3BCYP1A2CDK7 | |
| SCHEMBL26394024 | 0.80 | GSK3B (0.44) | HDAC6PAK1GSK3BCYP1A2CDK7 | |
| SCHEMBL26393960 | 0.80 | JAK2 (0.40) | HDAC6PAK1GSK3BCYP1A2PRKAA1 | |
| SCHEMBL26394010 | 0.80 | JAK2 (0.40) | HDAC6PAK1GSK3BCYP1A2PRKAA1 | |
| SCHEMBL26393947 | 0.79 | JAK2 (0.61) | HDAC6PAK1GSK3BCYP1A2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023186773-A1 | SUBSTITUTED 3-AMINO INDAZOLE DERIVATIVES AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-05 | — | — | WO | disclosed |