Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104057 | 0.82 | KMT2A (0.54) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL20976469 | 0.81 | KMT2A (0.57) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL1696919 | 0.79 | KMT2A (0.54) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL3049318 | 0.78 | KMT2A (0.66) | HPGDKMT2ACYP2C19HTTALDH1A1 | |
| SCHEMBL31680569 | 0.77 | KMT2A (0.89) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL11901003 | 0.77 | KMT2A (0.89) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL1032002 | 0.77 | MAPK1 (0.77) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL17481995 | 0.77 | KMT2A (0.51) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL5113787 | 0.76 | NPC1 (0.55) | HPGDTP53GLAKMT2ACYP3A4 | |
| SCHEMBL4774133 | 0.76 | MAPK10 (0.51) | HPGDGLAKMT2AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102666500-A | Seven-membered ring compound and pharmaceutical use therefor | DAIICHI SANKYO CO LTD | 2012-09-12 | — | — | CN | disclosed |