Paraoxon

Paraoxon

SCHEMBL26405

CCOP(=O)(OCC)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 1.00
CA2 P00918 2/20 1.00
BCHE P06276 1/20 1.00
ACHE P22303 1/20 1.00
ALDH1A1 P00352 3/20 0.69
MAPK1 P28482 3/20 0.69
CYP3A4 P08684 2/20 0.69
HSD17B10 Q99714 2/20 0.69
TSHR P16473 1/20 0.69
CES2 O00748 1/20 0.57
CES1 P23141 1/20 0.57
LMNA P02545 2/20 0.53
TP53 P04637 1/20 0.53
THRB P10828 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
PTGS2 P35354 1/20 0.50
KDM4E B2RXH2 1/20 0.47
BCL9 O00512 1/20 0.46
CTNNB1 P35222 1/20 0.46
POLB P06746 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Paraoxon SCHEMBL21114409 1.00 CA1 (1.00) CA1CA2BCHEACHEALDH1A1
SCHEMBL6259754 0.97 CA1 (0.94) CA1CA2BCHEACHEALDH1A1
Paraoxon SCHEMBL2597104 0.91 MAPK1 (0.86) CA1CA2BCHEACHEALDH1A1
Paraoxon SCHEMBL4750760 0.90 CA1 (0.81) CA1CA2BCHEACHEALDH1A1
Paraoxon SCHEMBL6925976 0.88 CA1 (0.77) CA1CA2BCHEACHEALDH1A1
SCHEMBL3233444 0.86 CA1 (0.75) CA1CA2BCHEACHEALDH1A1
SCHEMBL2596732 0.85 CA1 (0.74) CA1CA2BCHEACHEALDH1A1
SCHEMBL11310035 0.84 CA1 (0.71) CA1CA2BCHEACHEALDH1A1
P-Nitrophenyl-O-Ethyl Ethylphosphonate SCHEMBL29350630 0.84 CA1 (0.72) CA1CA2BCHEACHEALDH1A1
SCHEMBL6267678 0.84 CA1 (0.72) CA1CA2BCHEACHEALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6088 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122081445-A High-flux toxicity pre-evaluation substitution method based on neuropathy target esterase target 2026-05-26 CN claimed
EP-4723893-A2 COMPOSITIONS AND METHODS TO MITIGATE PHYTOTOXIC EFFECTS OF AGRICHEMICALS Ascribe Bioscience Inc. (US) 2026-04-15 EP claimed
EP-4637935-A1 SOLID COMPOSITION, METHOD AND USE FOR DETOXIFYING A CHEMICAL WARFARE AGENT (CWA) AND METHOD OF MANUFACTURE OF SOLID COMPOSITION PolyCatUK Ltd. (GB) 2025-10-29 EP claimed
US-20250186608-A1 NANODIAMONDS AS DELIVERY PLATFORM FOR OXIME ANTIDOTES TO CENTRAL NERVOUS SYSTEM IN ORGANOPHOSPHATE POISONING TALLINN UNIVERSITY OF TECHNOLOGY (EE) 2025-06-12 US claimed
CN-119259099-B Cerium-based nano-enzyme, preparation method thereof and application thereof in organophosphorus pesticide detection 山东第一医科大学(山东省医学科学院) 2025-04-22 CN claimed
US-20250114653-A1 COMPOSITIONS, METHODS, AND ARTICLES COMPRISING COCAINE ESTERASE FOR DETOXIFYING AN ORGANOPHOSPHATE-BASED AGENT FOUR WINDS BIOTHERAPEUTICS, INC. 2025-04-10 US claimed
CN-119780005-A Visual rapid detection method of carbosulfan by medium-entropy nano enzyme and application thereof 南昌大学 2025-04-08 CN claimed
CN-119688888-A Method for detecting 146 pesticide residues in animal food by using dispersive solid-phase extraction-gas chromatography-mass spectrometry technology 兰州市食品药品检验检测研究院 2025-03-25 CN claimed
CN-118681601-B ZrCu-MOG material for cascade degradation of organophosphorus nerve agents and preparation method and application thereof 重庆师范大学 2025-01-24 CN claimed
CN-114295741-B Method for simultaneous quantitative analysis of travoprost and travoprost acid contained in solution sample 沈阳兴齐眼药股份有限公司 2025-01-10 CN claimed
EP-0876603-A1 ELECTRODES AND METALLO ISOINDOLE RINGED COMPOUNDS CANADIAN BIOCONCEPTS, INC. (CA) 1998-11-11 EP claimed
WO-1998029424-A1 PREPARATION OF CYANOPHOSPHONATES FROM PHOSPHATES AND CYANIDE MONSANTO COMPANY (US) 1998-07-09 WO claimed
EP-0453515-B1 COMPOSITION FOR TREATMENT OF SENILE DEMENTIA PANG PETER K T (CA) 1998-04-01 EP claimed
WO-1997027473-A1 ELECTRODES AND METALLO ISOINDOLE RINGED COMPOUNDS CANADIAN BIOCONCEPTS, INC. (CA) 1997-07-31 WO claimed
US-5510247-A ROTATABLE CHEMICAL REACTOR CONTAINING A WATER IN OIL EMULSION HAVING CATALYST IN FIRST PHASE AND LIQUID TO BE REMOVED THROUGH OUTLET IN THE SECOND PHASE; EXTRACTION, ENZYMATIC BIODEGRADATION UNIVERSITY OF PITTSBURGH (US) 1996-04-23 US claimed
EP-0651055-A2 Uses of modified cholinesterase and compositions containing them State of Israel Represented by the Prime Minister's Office The Israel Institute for Biological Research (IL) 1995-05-03 EP claimed
US-5137878-A Composition and method for treatment of senile dementia PANG, PETER K. T. (CA) 1992-08-11 US claimed
EP-0453515-A4 COMPOSITION AND METHOD FOR TREATMENT OF SENILE DEMENTIA 1992-05-06 EP claimed
EP-0453515-A1 COMPOSITION FOR TREATMENT OF SENILE DEMENTIA PANG, Peter K. T. (CA) 1991-10-30 EP claimed
WO-1990008315-A1 COMPOSITION AND METHOD FOR TREATMENT OF SENILE DEMENTIA PANG PETER K T (CA) 1990-07-26 WO claimed