Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.49 |
| ▸ | TP53 | P04637 | 8/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640808 | 0.82 | MAPT (0.52) | MAPTTP53POLBALOX5APNPC1 | |
| SCHEMBL2640759 | 0.82 | LMNA (0.59) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL2641004 | 0.81 | NPC1 (0.52) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL2360618 | 0.80 | NPC1 (0.65) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL2360887 | 0.80 | MAPT (0.63) | MAPTTP53POLBALOX5APNPC1 | |
| SCHEMBL2360362 | 0.80 | MAPT (0.71) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL2640833 | 0.79 | MAPT (0.45) | MAPTTP53POLBALOX5APNPC1 | |
| SCHEMBL13362298 | 0.79 | MAPT (0.56) | MAPTTP53POLBALOX5APNPC1 | |
| SCHEMBL516209 | 0.79 | NPC1 (0.50) | MAPTTP53POLBNPC1RAB9A | |
| SCHEMBL516677 | 0.79 | MAPT (0.46) | MAPTTP53POLBALOX5APNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569309-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | Bayer Intellectual Property GmbH (DE) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141325-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |
| WO-2011141325-A1 | HYDROXYALKYL BENZYL PYRAZOLES, AND USE THEREOF FOR THE TREATMENT OF HYPERPROLIFERATIVE AND ANGIOGENIC DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2011-11-17 | — | — | WO | disclosed |