Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2640761 | 0.86 | OPRL1 (0.51) | OPRL1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL13229274 | 0.82 | OPRL1 (0.57) | OPRL1ALDH1A1TSHR | |
| SCHEMBL23203155 | 0.77 | OPRL1 (0.46) | OPRL1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL1356638 | 0.75 | OPRL1 (0.53) | OPRL1ALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL2053631 | 0.73 | OPRL1 (0.44) | OPRL1ALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL2042478 | 0.73 | OPRL1 (0.51) | OPRL1ALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL2640731 | 0.73 | OPRL1 (0.44) | OPRL1ALDH1A1TSHRNOS1HSD17B10 | |
| SCHEMBL2640769 | 0.73 | OPRL1 (0.48) | OPRL1ALDH1A1TSHRCYP2D6 | |
| SCHEMBL7695550 | 0.72 | OPRL1 (0.76) | OPRL1ALDH1A1CYP2D6 | |
| Alcohol SCHEMBL6978627 | 0.71 | OPRL1 (0.47) | OPRL1ALDH1A1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569316-A1 | PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | claimed |
| WO-2011143459-A1 | PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | claimed |
| EP-2569316-A1 | PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011143459-A1 | PYRROLOPYRIDINE AND PYRROLOPYRIMIDINE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | disclosed |