Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.56 |
| ▸ | CACNA1H | O95180 | 5/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26409151 | 0.91 | CACNA1H (0.66) | CACNA1IKCNH2CACNA1HCACNA1GLMNA | |
| SCHEMBL4284007 | 0.88 | CACNA1I (0.69) | CACNA1IKCNH2CACNA1HCACNA1GLMNA | |
| SCHEMBL26409156 | 0.85 | CACNA1H (0.55) | CACNA1IKCNH2CACNA1HCACNA1GLMNA | |
| SCHEMBL26083134 | 0.82 | CACNA1H (0.66) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL14763814 | 0.80 | CACNA1I (0.66) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL26082497 | 0.78 | CACNA1I (0.80) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL4271124 | 0.78 | CACNA1I (0.80) | CACNA1IKCNH2CACNA1HCACNA1GCYP2D6 | |
| SCHEMBL26081952 | 0.78 | KMT2A (0.43) | CACNA1IKCNH2CACNA1HCACNA1GLMNA | |
| SCHEMBL4279336 | 0.77 | MEN1 (0.55) | CACNA1IKCNH2CACNA1HCACNA1GCCR2 | |
| SCHEMBL4280401 | 0.77 | CCR2 (0.58) | CACNA1IKCNH2CACNA1HCACNA1GLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192675-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |