Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950276 | 0.84 | KMT2A (0.52) | KMT2ATDP1ALDH1A1LMNAHSD17B3 | |
| SCHEMBL2641159 | 0.78 | NPC1 (0.41) | KMT2ALMNANPC1RAB9AGFER | |
| SCHEMBL1949362 | 0.78 | LMNA (0.45) | KMT2AALDH1A1LMNAMEN1GAA | |
| SCHEMBL1950717 | 0.78 | KMT2A (0.49) | KMT2ATDP1NAMPTALDH1A1LMNA | |
| SCHEMBL2640599 | 0.76 | PARP1 (0.43) | KMT2ALMNANPC1RAB9AGFER | |
| SCHEMBL14871648 | 0.76 | HSD17B3 (0.54) | KMT2ATDP1ALDH1A1LMNAHSD17B3 | |
| SCHEMBL14871702 | 0.74 | KDM4E (0.60) | KMT2ATDP1ALDH1A1LMNAHSD17B3 | |
| SCHEMBL1951535 | 0.73 | KMT2A (0.48) | KMT2ATDP1ALDH1A1LMNAHSD17B3 | |
| SCHEMBL1951421 | 0.73 | LMNA (0.43) | KMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL2635196 | 0.71 | NPC1 (0.38) | KMT2AFLT3LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | claimed |