Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.67 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.67 |
| ▸ | CHRNA1 | P02708 | 3/20 | 0.67 |
| ▸ | CHRNG | P07510 | 3/20 | 0.67 |
| ▸ | CHRNB1 | P11230 | 3/20 | 0.67 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.67 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.67 |
| ▸ | CHRND | Q07001 | 3/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 9/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 7/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229952 | 0.95 | CHRNB2 (0.73) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2639017 | 0.93 | CHRNB2 (0.73) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2641063 | 0.92 | CHRNB2 (0.66) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL6255251 | 0.91 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1616562 | 0.90 | CHRNB2 (0.82) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1616871 | 0.89 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2639225 | 0.88 | CHRNB2 (0.68) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1617142 | 0.86 | CHRNB2 (0.90) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1557278 | 0.86 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 | |
| SCHEMBL1557335 | 0.85 | CHRNB2 (0.92) | CHRNB2CHRNA4CHRNA1CHRNGCHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4749715-B2 | — | — | 2011-08-17 | — | — | JP | claimed |
| EP-1519939-A2 | N-ARYL DIAZASPIRACYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | Targacept, Inc. (US) | 2005-04-06 | — | — | EP | claimed |
| WO-2004005293-A2 | N-ARYL DIAZASPIRACYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. (US) | 2004-01-15 | — | — | WO | claimed |
| EP-1519939-A2 | N-ARYL DIAZASPIRACYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | Targacept, Inc. (US) | 2005-04-06 | — | — | EP | disclosed |
| WO-2004005293-A2 | N-ARYL DIAZASPIRACYCLIC COMPOUNDS AND METHODS OF PREPARATION AND USE THEREOF | TARGACEPT, INC. (US) | 2004-01-15 | — | — | WO | disclosed |