Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791820 | 0.84 | CYP17A1 (0.50) | HCAR1PDE10AALDH1A1CYP17A1LCK | |
| SCHEMBL2641867 | 0.77 | PDE10A (0.46) | CYP2A6TP53PDE10ACYP1A2CYP3A4 | |
| SCHEMBL23362164 | 0.75 | TP53 (0.44) | HCAR1TP53PDE10AKDM4EAKT1 | |
| SCHEMBL21135046 | 0.75 | AKT1 (0.46) | HCAR1KDM4EALDH1A1AKT1TSHR | |
| SCHEMBL10094611 | 0.73 | HCAR1 (0.50) | HCAR1TP53PDE10AKDM4ECYP1A2 | |
| SCHEMBL884415 | 0.72 | KCNA5 (0.49) | TP53 | |
| SCHEMBL884719 | 0.71 | KCNA5 (0.39) | HCAR1TP53PDE10AKDM4ECYP17A1 | |
| SCHEMBL2193768 | 0.70 | HCAR1 (0.52) | HCAR1PDE10AALDH1A1 | |
| SCHEMBL884723 | 0.70 | TP53 (0.39) | HCAR1TP53PDE10AKDM4ECYP17A1 | |
| SCHEMBL10094304 | 0.70 | HCAR1 (0.53) | HCAR1TP53PDE10AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0563001-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | claimed |
| EP-0563001-A1 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-29 | — | — | EP | claimed |
| EP-0563001-B1 | Imidazole compounds, their preparation and use | NEUROSEARCH AS (DK) | 1996-02-28 | — | — | EP | disclosed |
| US-5360809-A | Imidazole compounds and their use as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-11-01 | — | — | US | disclosed |
| EP-0563001-A1 | Imidazole compounds, their preparation and use | NEUROSEARCH A/S (DK) | 1993-09-29 | — | — | EP | disclosed |