SCHEMBL2641913

SCHEMBL2641913

O=C(O)NCc1ccc(/C=C/c2ccc(F)nc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 4/20 0.43
HDAC8 Q9BY41 4/20 0.43
HDAC6 Q9UBN7 3/20 0.43
HDAC1 Q13547 3/20 0.41
HDAC2 Q92769 3/20 0.41
ALDH1A1 P00352 2/20 0.41
MAPT P10636 1/20 0.41
MMP1 P03956 2/20 0.41
MMP2 P08253 2/20 0.41
MMP9 P14780 2/20 0.41
KDM4E B2RXH2 1/20 0.41
CYP1A2 P05177 2/20 0.41
CYP2C9 P11712 2/20 0.41
CYP2D6 P10635 1/20 0.41
TSHR P16473 1/20 0.41
CYP2C19 P33261 1/20 0.41
HDAC4 P56524 2/20 0.40
HDAC7 Q8WUI4 2/20 0.40
HDAC10 Q969S8 2/20 0.40
HDAC11 Q96DB2 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2641915 1.00 HDAC3 (0.43) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL27033246 0.84 HDAC1 (0.46) HDAC1ALDH1A1CYP1A2CYP2C9CYP2D6
SCHEMBL2641827 0.82 HDAC1 (0.44) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641917 0.82 HDAC3 (0.41) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641924 0.82 HDAC3 (0.41) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641902 0.82 L3MBTL1 (0.52) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641908 0.82 L3MBTL1 (0.52) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641833 0.82 HDAC1 (0.44) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641767 0.82 KDM4E (0.41) HDAC3HDAC8HDAC6HDAC1HDAC2
SCHEMBL2641775 0.82 KDM4E (0.41) HDAC3HDAC8HDAC6HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011141515-A1 DIAGNOSTIC AGENTS FOR AMYLOID BETA IMAGING BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2011-11-17 WO disclosed