Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19226402 | 1.00 | MEN1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL14392680 | 0.84 | PDK2 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1PDK2 | |
| SCHEMBL22184356 | 0.84 | PDK2 (0.52) | MEN1KMT2ASMN1; SMN2ALDH1A1PDK2 | |
| SCHEMBL14924420 | 0.84 | KDM1A (0.63) | MEN1KMT2AALDH1A1HPGDPDK2 | |
| SCHEMBL22859014 | 0.83 | POLB (0.54) | KMT2AHTTHPGDPDK2KDM1A | |
| SCHEMBL1448240 | 0.83 | PDK2 (0.51) | MEN1KMT2APDK2KDM1A | |
| SCHEMBL2132882 | 0.82 | EPHX1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2132888 | 0.82 | EPHX1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7881494 | 0.82 | EPHX1 (0.63) | MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4618429 | 0.82 | MEN1 (0.59) | MEN1KMT2ARAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | WEE2, WEE1, HK1 | MEN1 929/4885KMT2A 3655/4885RAB9A 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.