Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.59 |
| ▸ | NAMPT | P43490 | 1/20 | 0.56 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4618143 | 0.93 | MEN1 (0.68) | MEN1KMT2ANAMPTNPC1L1RAB9A | |
| SCHEMBL31267093 | 0.89 | NAMPT (0.57) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL31267054 | 0.89 | NAMPT (0.57) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL24185784 | 0.88 | NAMPT (0.56) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL24185232 | 0.88 | NAMPT (0.56) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL24185215 | 0.88 | NAMPT (0.56) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL2610266 | 0.88 | NAMPT (0.61) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL7939466 | 0.88 | NAMPT (0.61) | MEN1KMT2ANAMPTNPC1L1PARP1 | |
| SCHEMBL12644375 | 0.86 | NAMPT (0.70) | MEN1KMT2ANAMPTNPC1L1RAB9A | |
| SCHEMBL16771644 | 0.85 | NAMPT (0.53) | NAMPTNPC1L1PARP1CYP2C9HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | MEN1 886/4885KMT2A 3832/4885NAMPT 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.