Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30407330 | 1.00 | NPC1 (0.47) | NPC1HTTRAB9ACA12CA1 | |
| SCHEMBL31024154 | 0.86 | NPC1 (0.55) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26087633 | 0.86 | NPC1 (0.55) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL30408238 | 0.84 | HTT (0.48) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26425968 | 0.84 | HTT (0.48) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26425656 | 0.80 | NPC1 (0.54) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL30408552 | 0.79 | NPC1 (0.53) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26134387 | 0.79 | NPC1 (0.53) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26425647 | 0.78 | NPC1 (0.63) | NPC1HTTRAB9AALDH1A1KDM4E | |
| SCHEMBL26090158 | 0.77 | HTT (0.61) | NPC1HTTRAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302414-A | Oxazole, oxadiazole and indole derivatives useful for inhibiting USP28 | 卡莫特医疗有限公司 | 2024-07-05 | — | — | CN | disclosed |
| WO-2023069721-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | CARMOT THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |