Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26087633 | 0.85 | NPC1 (0.55) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL31024154 | 0.85 | NPC1 (0.55) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL30407330 | 0.80 | NPC1 (0.47) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26425660 | 0.80 | NPC1 (0.47) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26090397 | 0.80 | NPC1 (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26425647 | 0.80 | NPC1 (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26090239 | 0.80 | HTT (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL26090728 | 0.80 | HTT (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL31024148 | 0.80 | HTT (0.63) | NPC1RAB9AHTTERCC1ERCC4 | |
| SCHEMBL30407337 | 0.79 | RAB9A (0.51) | NPC1RAB9AHTTERCC1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023069721-A2 | OXAZOLE, OXADIAZOLE, AND INDOLE DERIVATIVES FOR THE INHIBITION OF USP28 | CARMOT THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |