Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26424685 | 0.87 | TSHR (0.60) | TSHRPOLBRAB9AEPHX1SMN1; SMN2 | |
| SCHEMBL26424683 | 0.79 | SMN1; SMN2 (0.58) | TSHRPOLBRAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL23962408 | 0.76 | TSHR (0.57) | TSHRPOLBRAB9ACYP1A2CYP2C9 | |
| SCHEMBL1665145 | 0.75 | TSHR (0.55) | TSHRPOLBRAB9ACYP1A2CYP2C9 | |
| SCHEMBL13342931 | 0.70 | RAB9A (0.67) | TSHRPOLBRAB9ACYP1A2CYP2C9 | |
| SCHEMBL8247308 | 0.69 | CYP1A2 (1.00) | TSHRPOLBRAB9ACYP1A2CYP2C9 | |
| SCHEMBL1665636 | 0.69 | SMN1; SMN2 (0.60) | TSHRRAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31717524 | 0.69 | RAB9A (0.83) | TSHRRAB9ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5646041 | 0.69 | RAB9A (0.74) | TSHRPOLBRAB9ACYP1A2CYP2C9 | |
| SCHEMBL4599565 | 0.68 | EPHX1 (0.68) | TSHRRAB9ACYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | WEE2, WEE1, HK1 | TSHR 4772/4885POLB 3942/4885RAB9A 3408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.