⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3313074 | 0.78 | — | — | |
| SCHEMBL23586974 | 0.73 | — | — | |
| SCHEMBL881429 | 0.73 | — | — | |
| SCHEMBL3318734 | 0.73 | — | — | |
| SCHEMBL14748122 | 0.72 | — | — | |
| SCHEMBL1780853 | 0.71 | — | — | |
| SCHEMBL16130070 | 0.71 | NEK2 (0.31) | — | |
| SCHEMBL28258089 | 0.71 | TSHR (0.36) | — | |
| SCHEMBL25294321 | 0.71 | TSHR (0.36) | — | |
| SCHEMBL26430743 | 0.67 | KDM4E (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018057-B2 | Peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory diseases | JANSSEN BIOTECH, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230129095-A1 | PEPTIDE INHIBITORS OF INTERLEUKIN-23 RECEPTOR AND THEIR USE TO TREAT INFLAMMATORY DISEASES | PROTAGONIST THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | US | disclosed |
| CN-107922388-A | Compounds and compositions for inhibiting SHP2 activity | 诺华股份有限公司 | 2018-04-17 | — | — | CN | disclosed |