Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Medetomidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.50 |
| ▸ | ADRA2B known ✓ | P18089 | 4/20 | 0.50 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Medetomidine SCHEMBL18497244 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL29431568 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL12092460 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL119382 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Medetomidine SCHEMBL787913 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL14861666 | 1.00 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL14080529 | 0.98 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Medetomidine SCHEMBL22616139 | 0.98 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Dexmedetomidine SCHEMBL22476079 | 0.98 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| Medetomidine SCHEMBL204843 | 0.98 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7591 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029243-A | Antifouling coating composition and antifouling coating film | 日本油漆船舶涂料公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4735541-A1 | ANTIFOULING COMPOSITION | Jotun A/S (NO) | 2026-05-06 | — | — | EP | claimed |
| EP-4728012-A1 | APPLICATION OF A BIOCIDE-CONTAINING FOULING CONTROL COMPOSITION BY ELECTROSTATIC SPRAYING | PPG Coatings Europe B.V. (NL) | 2026-04-22 | — | — | EP | claimed |
| EP-3805327-B1 | ANTIFOULING PAINT COMPOSITION | MITSUBISHI CHEM CORP (JP) | 2026-04-15 | — | — | EP | claimed |
| EP-3671287-B1 | MEDETOMIDINE COMPOSITIONS HAVING IMPROVED ANTI-FOULING CHARACTERISTICS | PGS GEOPHYSICAL AS (NO) | 2026-03-18 | — | — | EP | claimed |
| EP-4704839-A2 | IMIDAZOLE CONTAINING COMPOUNDS, DERIVATIVES THEREFORE, AND USES THEREOF | ALPHERABIO LLC (US) | 2026-03-11 | — | — | EP | claimed |
| US-20260062562-A1 | SYSTEM FOR PRODUCING SUPERHYDROPHOBIC RUBBER AND PLASTIC COMPOUNDS WITH ANTIFOULING PROPERTIES | BARNACLE BLOCKER LLC (US) | 2026-03-05 | — | — | US | claimed |
| US-12565590-B2 | Antifouling coating composition and antifouling coating film | NIPPON PAINT MARINE COATINGS CO., LTD. (JP) | 2026-03-03 | — | — | US | claimed |
| US-20260041092-A1 | Composition Protecting Wood Against Marine Woodborers | I-TECH AB (SE) | 2026-02-12 | — | — | US | claimed |
| US-12501899-B2 | Mite infestation treatment | VETO-PHARMA (FR) | 2025-12-23 | — | — | US | claimed |
| US-4910214-A | Sedative, analgesics | FARMOS YHTYMA OY (FI) | 1990-03-20 | — | — | US | claimed |
| EP-0331374-A2 | 4-substituted imidazole derivatives useful in perioperative care | ORION-YHTYMÀ OY (FI) | 1989-09-06 | — | — | EP | claimed |
| EP-0300652-A1 | Optical isomer of an imidazole derivative | ORION-YHTYMÀ OY (FI) | 1989-01-25 | — | — | EP | claimed |
| CN-1030576-A | Separation of optical isomers of imidazole from racemic modification | FARMOS OY (FI) | 1989-01-25 | — | — | CN | claimed |
| US-4783477-A | MEDETOMIDINE | FARMOS-YHTYMA OY (FI) | 1988-11-08 | — | — | US | claimed |
| EP-0270267-A2 | Anxiolytic composition | ORION-YHTYMÀ OY (FI) | 1988-06-08 | — | — | EP | claimed |
| EP-0187471-A2 | Use of a substituted imidazole for the manufacture of a medicament useful as a sedative or analgesic | ORION-YHTYMÀ OY (FI) | 1986-07-16 | — | — | EP | claimed |
| EP-0072615-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos Group Ltd. (FI) | 1985-12-27 | — | — | EP | claimed |
| US-4544664-A | Antihypertensive substituted imidazole derivatives | FARMOS GROUP, LTD. (FI) | 1985-10-01 | — | — | US | claimed |
| EP-0072615-A1 | Substituted imidazole derivatives and their preparation and use | Farmos Group Ltd. (FI) | 1983-02-23 | — | — | EP | claimed |