Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64414 | 0.86 | HCAR3 (0.71) | MAPK1HCAR3ROCK1KDM4EL3MBTL1 | |
| SCHEMBL26436204 | 0.83 | HCAR3 (0.76) | HCAR3GRM5 | |
| SCHEMBL23999861 | 0.80 | KMT2A (0.57) | MAPK1ROCK1KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL989845 | 0.79 | GRM5 (0.62) | MAPK1HCAR3ROCK1KDM4EL3MBTL1 | |
| SCHEMBL4871031 | 0.79 | ROCK1 (0.62) | ROCK1KDM4ENPC1RAB9AMEN1 | |
| SCHEMBL29498889 | 0.77 | MAPK1 (0.48) | MAPK1HCAR3ROCK1KDM4EL3MBTL1 | |
| SCHEMBL22235635 | 0.77 | MAPK1 (0.48) | MAPK1HCAR3ROCK1KDM4EL3MBTL1 | |
| SCHEMBL6984008 | 0.77 | HCAR3 (0.68) | MAPK1HCAR3KDM4EL3MBTL1ALDH1A1 | |
| SCHEMBL8506592 | 0.76 | MEN1 (0.55) | ROCK1KDM4EALDH1A1MAPTIKBKE | |
| SCHEMBL22236084 | 0.76 | KDM4E (0.51) | MAPK1HCAR3KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230127046-A1 | G9a INHIBITOR | RIKEN (JP) | 2023-04-27 | — | — | US | disclosed |
| US-20230127046-A1 | G9a INHIBITOR | RIKEN (JP) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230127046-A1 | G9a INHIBITOR | EZH2, BMI1, DOT1L | MAPK1 1495/4885HCAR3 4650/4885ROCK1 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.