SCHEMBL26437646 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	HRH3	Q9Y5N1	2/20	0.54

▸	SUV39H2	Q9H5I1	6/20	0.46

▸	PIK3C3	Q8NEB9	1/20	0.44

▸	AOC3	Q16853	1/20	0.43

▸	CDK1	P06493	1/20	0.42

▸	CDK2	P24941	1/20	0.42

▸	F10	P00742	1/20	0.41

▸	QPCT	Q16769	1/20	0.40

▸	MAPT	P10636	1/20	0.40

▸	ABL1	P00519	1/20	0.39

▸	MAT2A	P31153	1/20	0.39

▸	HSD11B1	P28845	1/20	0.38

▸	ACKR3	P25106	1/20	0.38

▸	SYK	P43405	1/20	0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL13336404	0.91	HRH3 (0.49)	HRH3SUV39H2PIK3C3AOC3CDK1
SCHEMBL26437457	0.91	HRH3 (0.49)	HRH3SUV39H2PIK3C3AOC3CDK1
SCHEMBL26437436	0.91	HRH3 (0.49)	HRH3SUV39H2PIK3C3AOC3CDK1
SCHEMBL26437555	0.84	HRH3 (0.45)	HRH3SUV39H2PIK3C3AOC3F10
SCHEMBL3785803	0.82	HRH3 (0.50)	HRH3SUV39H2PIK3C3AOC3F10
SCHEMBL26437835	0.79	HRH3 (0.47)	HRH3SUV39H2PIK3C3AOC3F10
SCHEMBL31696699	0.78	MEN1 (0.51)	HRH3SUV39H2AOC3F10
SCHEMBL26438713	0.78	TLR9 (0.48)	HRH3SUV39H2QPCT
SCHEMBL13407684	0.78	HRH3 (0.45)	HRH3SUV39H2AOC3F10MAPT
SCHEMBL22077848	0.78	HRH3 (0.59)	HRH3SUV39H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2023066204-A1	SIK INHIBITOR, COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF	上海美悦生物科技发展有限公司	2023-04-27	—	—	WO	disclosed