Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2599460 | 0.82 | KMT2A (0.64) | PTGS1PTGS2 | |
| SCHEMBL2645397 | 0.81 | PTGS1 (0.41) | PTGS1 | |
| SCHEMBL2646659 | 0.81 | PTGS1 (0.56) | PTGS1PTGS2 | |
| SCHEMBL13943052 | 0.77 | GSK3B (0.42) | PTGS1PTGS2 | |
| SCHEMBL13483246 | 0.77 | PRF1 (0.45) | — | |
| SCHEMBL6509069 | 0.76 | PTGS1 (1.00) | PTGS1PTGS2 | |
| SCHEMBL2645065 | 0.76 | PTGS1 (0.41) | PTGS1 | |
| SCHEMBL2646350 | 0.74 | PTGS1 (0.38) | PTGS1 | |
| SCHEMBL9195197 | 0.74 | PTGS1 (0.66) | PTGS1PTGS2 | |
| SCHEMBL2644564 | 0.73 | MEN1 (0.50) | PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | disclosed |
| US-6476030-B1 | Pyrazolo-triazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. | 2002-11-05 | — | — | US | disclosed |
| EP-1121361-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | Merck Sharp & Dohme Limited (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023449-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |