Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 13/20 | 0.42 |
| ▸ | CBFB | Q13951 | 6/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645184 | 0.93 | DHODH (0.40) | GCKCBFBPARP1DHODHPARP2 | |
| SCHEMBL2645652 | 0.92 | DHODH (0.37) | GCKPARP1DHODHPARP2CYP3A4 | |
| SCHEMBL2644582 | 0.92 | CBFB (0.44) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2644898 | 0.88 | GCK (0.53) | GCK | |
| SCHEMBL2645885 | 0.86 | GCK (0.40) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645338 | 0.86 | CBFB (0.45) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2645888 | 0.84 | CBFB (0.43) | GCKCBFBALDH1A1TP53CYP3A4 | |
| SCHEMBL2643868 | 0.83 | GCK (0.37) | GCKCBFBDHODHCYP3A4CYP2C19 | |
| SCHEMBL1657673 | 0.83 | GCK (0.45) | GCKCBFBPARP1DHODHPARP2 | |
| SCHEMBL2646321 | 0.83 | CBFB (0.43) | GCKCBFBALDH1A1TP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1702919-B1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2012-05-30 | — | — | EP | disclosed |
| EP-1702919-A1 | NOVEL 2-HETEROARYL-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-09-20 | — | — | EP | disclosed |